A new study revealed that a family of anti -inflammatory drugs may help spread viral infection, which highlights the need for careful study when these medications are given to patients with an active viral infection, as they may unintendedly to facilitate the spread of the virus.
The study was conducted by researchers from the Department of Clinical and Molecular Medicine at the Norwegian University of Science and Technology, and its results were published in the “NAR MOLECLAR Medicine” magazine, and the Yurrick Alert website was written about.
“We have discovered a sudden and dangerous side effect of a category of anti -inflammatory drugs. It can help viruses to spread more easily in the body,” says Dennis Caynov, a professor of clinical and molecular medicine department at the Norwegian University of Science and Technology and the study researcher.
These medications, which may increase the risk of viral infection, are widely used. It is known as Janus Kinase Inhibitors and includes a number of drugs.
“Among the viruses that affect the body more easily with the help of these medications: the Cracked Valley Fever virus, influenza A, the glandular virus, and the SARS-Coff-2 virus, the virus that causes the Coffee-19” virus, “says Kinov.
These viruses cause a dangerous and common viral infection, and may be very dangerous without unintended help.
Weakening the body’s defenses
Caenov and his colleagues described how these drugs can enhance viral infection. “Janeos Kenaz inhibitors of autoimmune diseases and inflammatory conditions such as rheumatoid arthritis are often described,” says Erlind Rumen, a physician at the Norwegian University of Science and Technology and the study researcher.
But it also weakens the body’s natural defenses against viruses. “In particular, these drugs are an important pathway for immunosuppressions that helps protect healthy cells from viral attacks,” added.
Researchers have found that drugs such as Paricitinib slow the genes that respond to viral infection. “These genes play a decisive role in the body’s response to viral infection,” said Alexander Ianifesky, a researcher at the Norwegian University of Science and Technology and co -author of the new study.
By stopping or slowing this signal path, Janeos Kinaz inhibitors remove the antiviral shield in the body. Hence, viruses can settle and spread more easily.
Researchers used advanced techniques in virus and organ technology and genetic expression analysis. They examined cells of the lungs, eyes and brain, as well as small -made organs in the laboratory.
“Despite the effectiveness of Janus Kinaz inhibitors in the treatment of inflammation, this shows that they may pose a hidden danger to patients with an inherent or active viral infection,” says Rullo.
The results indicate the necessity of cautious health care workers when describing the Janus Kinaz inhibitors, especially during the spread of viruses.
The researchers hope to raise awareness among doctors and researchers about the effects of these drugs. “We recommend conducting more studies to understand how these medications are optimally used, especially during the spread of viruses or epidemics,” said Iyanvsky.