Scientists from the University of “Miami” announced the discovery of a promising treatment method for combating colon and rectal cancer, which is one of the most dangerous and widespread types of cancer.
During their studies to search for new treatments, scientists concluded that the use of Selinexor in conjunction with IRINOTECAN chemical, contributes greatly to reducing the sizes of cancerous tumors, especially colon cancer. The researchers focused on studying a boom in the XPO1 (XPO1), which plays a pivotal role in cellular transport, as it was found that this mutation makes cancer cells resistant to Irinotecan by enhancing DNA mechanisms (DNA), however, Selinexor – a gene (XPO1) – has shown a noticeable ability to curb the activity of these cells, and when combined with it with it Irinotican, significantly increased anti -hip effect.
The research team pointed out that the effectiveness of this drug mixture is not only limited to the presence of the genetic mutation, but also extends to the tumors where protein levels (XPO1) rise. Within the framework of their future plans, scientists intend to study the combination of Selinexor and immunotherapy, and testing the effectiveness of this method of treating other types of tumors, including endometrial cancer.
