A team of researchers in the United States found that environments where oxygen rates in the air decrease can enhance brain cells and help Parkinson’s patients (Parkinson’s) restore the ability to move.
This new scientific research has long -standing medical assumptions on the role of oxygen in neurodegeneration, and may allow new methods to treat paralysis patients around the world.
The researchers from the Broad Research Institute and the Mass GM Hospital in the United States found that placing the experimental mice infected with paralysis diseases in an environment in which the oxygen rate, such as air at the Al -Qaeda camp at the foot of Mount Everest, can protect cells, but rather helps in restoring motor capabilities.
According to the study published by the scientific journal “Neuroscience” specializing in diseases of the nervous system, the disruption of nerve functions in the body may increase the oxygen molecules in the brain, and it appears that excess oxygen speeds the nervous degeneration, while lack of oxygen may help in slowing the symptoms of the disease, and even improves them.
“The improved damage in the nerve systems that we found during the experiment is in fact an exciting issue,” says researcher Famsi Matta, a member of the Broad Research Institute and professor of regulations at Harvard University, adding in statements to the website “Saitik Daily” specializing in scientific research. “This experience revealed to us that there is a window of hope for the neurons that have been disrupted but still alive, We can restore the functions of these cells if we enter in time. “
“These results offer the possibility of a fully new scientific pattern to treat Parkinson’s paralysis.”. Although these results are promising, researchers say that it is still very early to try it on patients directly, and they warned against breathing the air in which the oxygen rate decreases without medical supervision, especially since in certain cases such as sleep may be harmful, but may exacerbate the health condition of the patients. The researchers hope that this study will eventually result in inventing drugs that can resist the benefit from a lack of oxygen.
Mitochondria imbalances
The study is based on research carried out by Maitha and other researchers over a period of ten years regarding what is known as hypoxia, a medical condition in which the oxygen in the tissues decreases from its usual rates, and the consequent in this case the body protection is known as “mitochondria imbalances”, and it is intended by a group of diseases that affect the function of the mitochondria as the energy factory inside the living cells.
“We initially found that a lack of oxygen can reduce the symptoms of some rare diseases that affect mitochondria such as Leigh Syndrome and Freidreich Ataxia, which are genetic diseases that affect the nervous system,” says. Like Parkinson’s? “
Parkinson’s disease affects more than 10 million people around the world and leads to a gradual deterioration in the brain’s neurons, causing the extremities of the ends and poor movement. In the event of this disease, toxic protein formations accumulate on sick nerve cells known as “Low’s bodies”, and biochemistry research indicates that these formations affect the function of mitochondria as it happens in other medical conditions that is known to be treated by hypoxia.
Some scientific observations have found that the health condition of Parkinson’s patients is improving in high places, and it also appears that smokers have long been high in carbon monoxide rates with a lack of oxygen in the tissues. They decrease the risk of Parkinson’s. “Based on these scientific evidence, we have an interest in the effect of hypoxia on Parkinson’s disease.”
In the context of the study, researchers injected experiments with compositions of SYNUCLEIN proteins that help in forming “Louie’s bodies” with the division of mice into two categories, where the first category was breathing normal (oxygen with 21%) while the second category was breathing in private rooms where the oxygen rate was 11%, which is the same percentage in the natural air at an altitude of 16 thousand feet or equivalent 4800 meters.
Lowe’s bodies
The results of this experiment were dazzling, as it was found that the mice that were breathing naturally had a lobby bodies, nerve cell death and major problems in the kinetic capabilities, while the mice that breathed air with low oxygen rates that did not show any indications of the loss of neurons or poor movement, despite the large amount of Louis bodies.
Ishinoz stresses that these results indicate that the lack of oxygen will not prevent Lui’s bodies, but they will protect neurons from their harmful effect, which gives way to a new format for treating Parkinson’s without targeting Louis or Sinoclin proteins.
“It has been found to us that the abundance of oxygen in the brain may have a toxic effect, and that by reducing the rates of oxygen in general, we can prevent the fuel needed for cell damage,” he said, adding that “this scientific topic may not be suitable for treating all cases of nervous degeneration, but it is a strong concept that may help change our way of thinking about the methods of treating this type of disease.”