In an advanced step towards improving the diagnosis of mental illness, researchers have enabled the Long-REANG SEAQUENCING-LRS to detect genetic changes, opening new horizons for psychiatry.
The study was conducted by researchers from the Guardian Institute of Genetic Medicine in Children in the United States, and was published on April 9th in the American Journal of Psychiatry, and was written by the Yurrick Alert website.
The results showed a great potential benefit to use the long genetic sequence in psychological hospitals, as it can easily access genetic diagnoses and help doctors make better treatment decisions. The researchers also pointed out that this technique may contribute to accelerating genetic tests for patients with complex mental illnesses, especially for those who need specialized care.
What is the technology of the genome sequence?
Genome sequence technique is a comprehensive DNA (DNA) analysis process for the organism with the aim of determining the sequence of genetic rules that make up the genome (the entire genetic material of the organism). This technique is used to understand how genes and chromosomes are arranged in living organisms, allowing scientists and researchers to know genetic changes that may be related to genetic diseases or chronic diseases.
Genome sequence techniques include several advanced methods, such as:
- Short-READ Sequencement: A small part of the genome is read at a time and later collected to form a complete image of the genome.
- Long reading sequences: Longer parts of DNA can be read in one pass, allowing the discovery of complex genetic changes such as repetitions or deletion.
These techniques contribute to identifying genetic mutations, and explaining how these mutations affect the functions of genes and the health of individuals, which helps in diagnosing genetic diseases and treatment directed based on the genetic properties of the individual.
What researchers discovered?
The research team analyzed the genes of a 17 -year -old young man who was suffering from an autistic spectrum disorder and severe behavioral disorder, as he suffered from a group of severe symptoms, including psychosis, depression and anxiety.
Using long -reading genetic sequence technology, researchers discovered a complex genetic change in the RFX3 gene (RFX3), a gene associated with autism spectrum disorder.
The researchers were able to determine this change with higher accuracy than the traditional methods were provided by. This discovery helps to improve the understanding of the relationship between genetic changes and behavioral symptoms, which enhances the ability to customize treatments more accurately.