A team of Canadian scientists discovered a new and surprising way to improve blood sugar levels and reduce liver damage, by holding fuel produced by the intestine bacteria before damaging the body.
These results may open the door to new treatments for metabolic diseases such as type 2 diabetes and fatty liver disease.
The study was conducted by researchers at the University of McMaster, Laval University and the University of Ottawa in Canada, and its results were published in the magazine Cell Metabolism on July 29, and the Yurrick Alert website was written about.
The researchers showed that a molecule produced by intestinal microbes can sneak into the bloodstream and nourish the liver to produce more glucose (blood sugar) and fat.
The researchers noted a great improvement in controlling the level of blood sugar and lipid liver disease in obese mice when they developed a way to hold this molecule in the intestine before entering the body.
“This is a new development in the traditional metabolic path,” Jonathan Sherzer, co -author of the study and professor in the Department of Biochemistry and Biomedical Sciences at McMaster University.
He added: “We have known nearly a century ago that the muscles and liver exchange lactate (a molecule produced by muscles and glucose), a process called a Korean cycle. What we discovered is a new branch of that course, where the intestine bacteria also participate in this process.”
Korean course
The couple Karl Ferdinand Curie and the Birantsa Corrie Curie in 1947 were awarded the Nobel Prize in Physiology or Medicine for their work, which shows how the muscles of the body are produced lactate that nourishes the liver to produce blood sugar, which in turn returns to nourish the muscles.
This basic work is to explain how the muscles use a form of lactate known as “L-Lactate”, and how the liver uses blood glucose to communicate and exchange energy between them.
The Canadian team found that the obese mice-even people with obesity-have higher levels of a less well-known molecule, which is “de lactate” in their blood, and unlike the most common “L Lacatt”, most de lactat comes from the intestinal microbes, and it has been proven that it raises blood sugar and liver fat more severely.
The researchers devised to prevent this intestinal trap, which is a safe and vital decomposition polymer associated with “de lactat” in the intestine and prevents its absorption.
The mice that feed on this polymer showed a decrease in the level of glucose in the blood, less insulin resistance, and a decrease in liver inflammation and cirrhosis, all without changing their diet or weight.
“This is a completely new way to think about treating metabolism, such as type 2 diabetes and fatty liver disease. Instead of targeting hormones or liver directly, we object to a source of microbial fuel before damaging.”