Researchers have discovered giant parts of a previously discovered DNA, called “Inocles”, and it seems that these elements play a pivotal role in helping bacteria to adapt to the constantly changing mouth environment.
These results provide a new vision on how to colonize and continue to oral bacteria in the human body, with possible effects on health, diseases and microbium research.
The study was conducted by researchers from the Department of Computer Biology and Medical Sciences, the College of Graduate Studies for leading sciences, Tokyo University in Japan, and its results were published in the Nature Communications Journal of Nature Communications on August 11th, and the Yorik Alrt website was written about it.
The researchers gave their attention to a large group of salivary samples collected by the Yutaka Suzuki Laboratory of the Faculty of Graduate Studies of the Leader Science at Tokyo University in Japan.
The discovery of Anules was not easy, because traditional sequence methods divide genetic data, making it impossible to rebuild the big elements, to overcome this problem, apply the team long -reading sequence techniques, which can capture much longer parts of DNA.
A major achievement from co -researcher Nagsa Hamamoto, who has selectively developed a method of removal of human DNA from salivary samples, greatly improved the quality of the sequence of long clips of other DNA.
This allowed researchers to assemble the entire infinite genomics for the first time, which it turned out to be hosted by Streptococcus Salivarius, although the hosting of the host itself was difficult.
“We know that there are many different types of bacteria in the mouth microbiome, but many of its functions and means of implementation are still unknown. We discovered Anocles, an example of DNA outside the chromosomes and they are pieces of DNA present in the cells, in this case the bacteria, but outside its main DNA. It is similar to finding a book with additional margins installed on it, and we have just started, and we have begun Reading her to find out what she is doing. “
The team aims to develop stable methods of growing bacteria that contain an oocles, and it will allow them to study how it works, whether it can spread among individuals, and how it can affect cases of oral health such as caries and gum disease.