A new American study revealed that the Lemburexant drug that helps sleep can protect mice from observed brain damage to degenerative nerve disorders, such as Alzheimer’s disease.
It prevents the harmful Laborxant drug for the harmful accumulation of an abnormal form of protein – called Tau – in the brain, which reduces the known inflammatory brain damage that TOO causes it in Alzheimer’s disease.
Laborxant is one of the 3 sleep helps approved by the US Food and Drug Administration, and it suppresses the effect of orexins, which is small proteins that organize sleep through their association with orxine receptors. The lamborcant hits orxine receptors (two types 1 and 2).
Records are proteins on the surface of the cell that are associated with other molecules and organized the cell activity. It is known that these receptors play an important role in sleeping, waking and appetite sessions, as well as other physiological processes.
The study was conducted by researchers from Washington University in Saint -Louis in the United States in cooperation with the Japanese pharmaceutical company EISAI, and the results of the study were published on May 27 in the journal Nature Neuroscience, and was written by the Yurik Alert website.
The participating author in the study, Dr. David M. Holkitmann, Professor of Neuroscientists at Washington University: “We have long known that lack of sleep is a risk factor for Alzheimer’s disease.”
He added: “In this new study, we have shown that the Lamburxant drug improves sleep and reduces abnormal Tao levels, which seems to be the main cause of nervous damage that we see in Alzheimer’s disease and many of the disorders associated with it. We hope that this result will lead to more studies on this sleep -helped medicine, and develop new treatments that may be more effective than the current options, whether alone or In conjunction with other treatments available. “
Lack of sleep and Alzheimer’s disease
Holkitman and his team were among the first to identify the relationship between lack of sleep as a risk factor for Alzheimer’s disease and proteins such as amyloid and oo. In a previous study, they showed genetically exposed mice of the accumulation of amyloid and oo proteins, a distinctive feature of Alzheimer’s disease – that sleep deprivation increases this accumulation.
“The antibodies against the amyloid that we are currently using to treat patients in the early and light stages of Alzheimer’s definition are useful, but they do not slow down the disease to the extent that we want. We need ways to reduce the abnormal accumulation of Tao and the associated inflammation, and this type of sleep aid is worth more research. We are interested in knowing whether targeting both the amyloid and bac During a set of treatments it can be more effective in slowing down or stopping the progress of this disease. “
The study showed that improving the sleep of these mice using a lipurxant medicine appears to be preventive, as it reduced the accumulation of tuko tu and reduced the death of neurons associated with Alzheimer’s disease.
Tau protein accumulates in the brain in many neurological disorders, including Alzheimer’s disease, and causes inflammation and death of brain cells.
What does Laborxant do?
In the genetically exposed mice of the accumulation of the harmful tu protein, the mamburxant was reduced from brain damage compared to the control group mice (which did not receive the drug). For example, the mice that received the mamburxant showed an increase in the volume of fortresses – a part of the brain that is important to the formation of memories – by 30% to 40% compared to the control group mice.
And when comparing the mice that received the MPORXANT with a group of mice control and mice that receive a different sleep medicine, which is Zolpidem, which belongs to a different category of medicines, Zolbidim increased sleep, but had no preventive effects against Tau accumulation in the brain like those seen with Laborxant, which indicates that the type of sleep assistant -antagonist Orxin receptors- is the key to the production of preventive nerve effects. The researchers also found that beneficial effects were seen only in mice males.
The natural Tao is important in maintaining the structure and function of the neurons. When it is intact, it carries a small number of chemical signs called phosphate groups. But when Tao picks up many of these chemical signs, it can be clumped together, which leads to inflammation and death of neurons.
The researchers found that the Laborxant drug prevents the addition of excessive signs to the Tau protein by blocking orxine receptors, which helps it to maintain its health functions in the brain.
Holkitmann stated that his team continues to explore the reasons for observing the neurological effects of the treatment of mamburxant in mice only, and he expected that the gender contrast would be the result of that females of mice with the same genetic willingness to accumulate the TOO protein had a less severe nervous tray compared to male mice. Given the low damage in the beginning, the potential positive effects of the drug may have been less difficult.