A new study revealed the ability of beneficial intestinal bacteria to convert bile acids derived from cholesterol into strong compounds that promote immunity against cancer by blocking the signals of some hormones.
The study was conducted by researchers at the University of Will Cornell University in the United States, and its results were published on April 15 in the Cell magazine (Cell), and the Yorik Alert website was written about.
Touch of bacteria on bile acids
The liver produces primary bile acids and released in the intestine, where various groups of bacteria work together to adjust their chemical structure, and researchers suspected that these intestinal microbial adjustments can affect how bile acids work and their interaction with human signs paths.
To test this idea, the researchers began to explore all the adjustments caused by bacteria to bile acids, and to understand how these changes affect their biological roles, and it turned out that the bacteria of the intestine have huge potential.
“We have discovered more than 50 different molecules of bile acids modified by bowel microbes, many of which have not been determined before,” said Dr. Chun John Joe, associate professor of immunology in medicine in the Department of Diseases of the Digestive and Liver, Will Cornell Faculty and researcher participating in the study.
Hormone
Bile acids share the same steroidal structure with sexual hormones such as testosterone and estrogen. When the researchers tested 56 average zero acid they discovered, they found that one of them was hostile to the future of androgen, a molecule that interacts with sexual hormones to regulate many aspects of human growth.
The future of androgen is also in some immune cells, including T -cells, and previous studies have shown that blocking this future can enhance the ability of immune cells to fight tumors.
The researchers asked whether the bile acids are able to double this effect by linking and disabled the future of androgen, and to test this idea, they treated mice with bladder cancer using these vehicles, and noticed a strong anti -tumor response. Other analyzes revealed that modified bile acids have particularly strengthened the activity of T cells, which are the most able immune cells to kill cancer.