Scientists for the first time, using live human brain tissue, showed how a protein associated with Alzheimer’s disease can stick to the connections that connect and damage the brain cells. This innovative approach gives a rare and effective opportunity to study the early stages of Alzheimer’s disease in live human brain cells.
The study was conducted by researchers from Edinburgh University in the United Kingdom, and its results were published in the Nature Communications magazine on April 30, and the British Daily Mail was written about it.
An imbalance in the folding of protein in some way, which makes it involved in a different, improper way, and makes multiple copies of it gather together to form a huge non -soluble fibrous deposits such as amyloid beta, which causes damage to the brain.
In this study, small pieces of healthy human brain tissue were shown – gathered during routine neurosurgery operations – for the bita -toxic amyloid protein. The study found that the slight changes in the normal levels of beta amydida were sufficient to disable brain cells.
The researchers also discovered that the brain slices taken from the temporal lobe, a region known for its early influence in Alzheimer’s disease, release higher levels of another major patient protein called Tao.
Alzheimer’s disease is attacked nerve clamps, bonds that allow messages to flow between brain cells, which are vital to proper brain function, and foretold their loss strongly with low memory and thinking capabilities.
The researchers hope that this discovery will facilitate the test of experimental drugs before entering experiments on humans, which increases the chance to find medicines operating in the human brain.