Researchers at the University of Zurich have discovered that stem cell transplantation can treat damage caused by stroke.
Its useful effects include regeneration of neurons and the restoration of motor functions, which represents a prominent achievement in the treatment of brain disorders.
This study was conducted by researchers from the University of Zurich in Switzerland and the University of South California, the United States, and its results were published in the journal Nature Communichens on September 16, and was written by Yorik Alrt.
One in every 4 adults suffers from a stroke during their lives, which leaves great health damage such as paralysis or poor speech, because internal bleeding or lack of oxygen supply destroys brain cells irreversibly, and there are currently no treatments to fix this type of damage.
“For this reason, it is necessary to follow new therapeutic methods for possible brain regeneration after diseases or accidents,” says Christian Tenberg, the scientific head of the nervous degeneration department at the Institute of Renewal Medicine at the University of Zurich and the researcher participating in the study.
“Our results appear that neurons not only form new neurons, but also stimulate other renovations,” he added.
Studies have used human nerve stem cells, from which different types of nervous system cells can be formed. Stem cells were extracted from multi -capacity stimulating stem cells, which can be manufactured from natural human physical cells.
The researchers motivated a permanent stroke in mice, which are very similar to the symptoms of stroke in humans.
The animals are genetically modified so that the human stem cells do not reject. A week after stimulating the occurrence of a stroke, the research team planted neurons in the affected brain area, and monitored subsequent developments using a variety of imaging methods and biochemistry.
“We found that the stem cells remained alive throughout the 5 -week full analysis period, and most of them turned into neurons, which have already communicated with the already existing brain cells,” says Tenberg.
Researchers have also found other signs of regeneration that include the formation of new blood vessels, the reduction of inflammatory response, and the improvement of the integrity of the blood blood barrier.