Scientists showed for the first time that a protein helps the cell to prepare for division can stimulate the transmission of cancer from one organ to another, and scientists revealed that this protein in our cells is an early warning sign of aggressive cancers, and a possible new target of drugs that stop spreading.
The study was conducted by researchers from the University of Bronil in London in the United Kingdom, and their results were published in the Life Science Alliance on August 18, and the American magazine Newsweek was written about.
“Our data reveals a new role for the central SA-6 central body in the formation of cilia (building cell sensors), activating another protein, and invading cancer cells,” Parra Tanos, Biomedist at the University of Brunil, said in a statement.
High levels of protein lead to the growth of cells of the cells more and longer, and plays a role in building accurate structures that resemble hairs on the surface of the cell, which can stimulate signals that make cancer cells more aggressive.
The researchers explained that these cards activate a path known as the YAP/ TAZ, which controls genes that help tumors to grow and spread to other parts of the body.
“The main cause of death in cancer patients is a metastatic disease, which occurs when cancer cells invade tissues away from the main tumor, that is, they spread to another part of the body,” said Dr. Tanos.
She added: “We found that the high -level SI6 cells have become more invasive to other tissues, and that this invasion reflects the removal of cilia.”
The cancerous invasion
Searching the team about what happens when cells produce a copy of the SA6 protein that does not decompose.
They found that the cells increased their cilia in length, their movement increased and their shape changed significantly, to become more flat and flexible, all signs of a gas cell.
When scientists blocked the WayAB path or removed the cilia, the invasion of cancer decreased to almost non -existent levels.
Then they found the same pattern in the real lung cancer cells, which contain high levels of SA6 protein, and the removal of protein from this cellular strain derived from the patient has stopped the cancer ability to spread.
Tanos told Newsweek: “The new thing is that we have found a path organized by the SA6 protein, which is the Way AB/ T/ T -Zz path. The removal of the SS6 protein from one of the breeds of a small -cell lung cancer cells reduces the Wi -AP signals, and this is crucial because the WAP path is active in many types of cancer.”
The scientists added that because many types of human cancer contain high levels unusually from the SA6 protein, it is likely to be used as an indicator of metric cancer.
“Protein levels are organized through creation and decomposition, each cell contains proteins that regulate this, in the case of SA6 protein, there are specific processes aimed at decomposing protein, and may be absent or ineffective in some types of cancer,” Tanous said.
Top levels of Jin AAS6 are found in lung cancer, kidney cancer, diet, liver cancer, and adrenal cortex.
The researchers pointed out that understanding how to motivate the gene and cilia to invade cancer cells can also help in designing new treatments that depend on the signs of the cilia.
“We believe this allows us a new way to understand how cellular signals control the spread of cancer, this can lead to smarter treatments and better ways to predict any types of cancer that will become aggressive.”