Researchers from India and France manufactured a new boat called Infuzide, to fight antibiotic -resistant bacteria, and Infuzid showed an effectiveness against gram -positive bacteria in experiments on bacteria cultivated in the laboratory and mice, giving hope to provide new treatments for drug -resistant infection.
A laboratory bacteria can be distinguished by looking under a microscope after dyeing them with a gram, and the bacteria have a gram on a thick cell wall, and these cells acquire blue/purple color when dyeing with a gram dye. The bacteria have a gram of different growth patterns, and vary in the degree of resistance to antibiotics.
The study was conducted by researchers from the Chemical Chemistry Laboratory at the University of Toulouse in France, and the Central Institute for Medicines Research of the Scientific and Industrial Council in Landau, India.
The results of the study were published in the Microbiology Special on June 2, and the Yorik Alrt website was written on it.
The antibiotic resistance directly causes more than a million deaths annually, according to the World Health Organization, and Staphylococcus Aureus and intestinal coccles (Enterococcus SPP) can cause a serious infection acquired by hospitals and society, two types of positive bacteria that develop antibiotic resistance.
Activity on mice
The new compound showed activity against strains resistant to antibiotics from the staphylococcus and intestinal cluster in the laboratory and mice. In addition, the results indicate that Infuzid eliminates bacteria in ways that are different from other antibiotics, which may help reduce resistance.
Infuzid came as a culmination of the efforts of more than a decade of work by multiple specialized researchers in search of ways to create vehicles that can work against pathogens in ways similar to well -known drugs. These include hydrons, inorganic manufactured compounds, previous studies have shown that they have anti -bacterial activity, including against drug -resistant strains. The researchers made 17 new compounds containing hydrons, including Infuzid.
“We started the project as a cooperative project, looking for ways to manufacture vehicles and link them with compounds that may be biological activities,” said medical chemist Michel Baltas, who holds a PhD, from the Co -Chemical Laboratory at the University of Toulouse in France. In this study, he participated in this study, along with Sidharh Chopra, who holds a PhD from the Central Institute for Medicines Research of the Scientific and Industrial Council in Lanawo, India.
The researchers found that infuzid attacks bacterial cells specifically, compared the antibacterial effects of infozide with vanquicin, a powerful antibiotic that represents normative care in the treatment of anti -anti -anti -infections, and found that infuzid reduced the size of bacterial colonies quickly and effectively more than the standard drug.
The compound effectively reduced the census of bacteria in the tests of staphylococcus infections resistant to the skin of mice. The researchers stated that the decrease was greater when incorporating the enzyme with Linzolid, which is an artificial antibiotic, while the infuzide did not show a remarkable activity against pathogens negative grams.
The researchers made vehicles without the need for solvents, which may be expensive and dangerous to the environment. Baltas explained that the simplicity of chemical reactions will facilitate the production of large quantities for use in new treatments. He added: “I am sure that these interactions can be expanded.”
In addition, the group has been studying the effects of manufactured vehicles on other infectious diseases, including tuberculosis. “We have many other compounds candidate for the production of antimicrobial compounds,” said Baltas.