For decades, scientists have been thinking about a basic problem, which is how the human brain gets rid of the waste that it secretes during work and thinking throughout the day, which includes excess proteins and molecules that may turn into toxic substances in the event of not being disposed of, including the amyloid bita and oo proteins that are considered the basic causes of Alzheimer’s disease.
For the rest of the body’s organs, the lymphatic system gets rid of these waste where excess fluids move to the spleen, lymph nodes and other parts of the lymphatic system before it passes to the bloodstream so that it is disposed of, but this vital process cannot be done in the same way inside the brain due to what is known as the barrier separating the brain and blood, which is a protective cover that prevents the transmission of infection to the neurons inside the brain, but it also prevents the transmission of anything outside the brain.
In 2012, a research team at the University of Rochester, headed by a neuroscientist Makeon Nedergard, reached a periodic system that was not previously known to expel toxic waste from the brain. It was found through research on experimental mice the flow of spermatic liquid into tunnels around the blood vessels in the brain, as these channels pass on the quality of the brain cells known as the star cells and mixed with what is known as the “Interestitial Fluids”, where they collect waste and carry them outside the brain through the areas around the blood vessels.
In 2013, Nedergard published an important study that the home cleaning process is active during the night. “While waking up the cleaning process, the reason is most likely that the accuracy of the work of the neural systems needed to address the influences of the external world is not compatible with the process of washing.”
These results confirm that the recently discovered brain washing process is one of the most important benefits of sleep. “When you wake up when you feel active after a period of calm sleep, this is likely that the brain has been reseting similar to what is happening in the case of maintenance of the car,” she explains.
But these previous studies were conducted on mice whose minds are smaller and less complicated than human minds, just as their sleep periods are usually intermittent and not connected like humans, and therefore many scientists rejected the theory of washing the human mind during sleep.
“10 years ago, talking about fluid flow inside the brain appears to be like heresy,” says Jonathan Kibinis, a nervous science specialist at Washington University College of Medicine. The researchers have spent the past ten years studying whether the process of washing brain occurred in a person similar to what is happening in the case of mice. Research has found to prove the validity of this theory, and even the electrical waves that move inside the brain during sleep, pushing the sliced fluid inside and outside the brain.
The “Glemvawi” system
For his part, Jeffrey Elev, a professor of psychiatry and nerves at the University of Washington, stresses the importance of what is known as the “Glemvavi” system, which means the mechanism for cleaning the brain and removing waste that takes place during human sleep. He says in statements to the “Scientific American” website that the disruption of this system probably leads to neurological and psychological disorders, including Alzheimer’s disease, and believes that the disruption of the glyfavia system may explain the cause of the brain storage of amyloid and oo proteins in the aging stage.
The researcher Eleve stated that for many years sleep specialists focusing on the importance of sleeping in the process of storing memories, and that the doctors who studied the spaces surrounding the blood vessels did not clearly intend to be intended, but rather greatly excluded the possibility that these spaces in fact be channels for the passage of fluids, adding that they “did not realize the dynamics of these channels.”
The researchers say that the human body produces between 3 to 4 times its stored from sperm liquids every day and then gets rid of them, and some early studies have realized the connection of the flow of these fluids with the heartbeat, but during previous studies it was not clear the change that occurs in the flow of these fluids during sleep.
During the experiment conducted by researcher Nidrard to measure the rates of elaboa proteins during the waking of mice, their sleep and their anesthesia, the researchers injected Florian followers into mice necks to follow the flow of sophisticated fluids inside the spaces around the blood vessels, and it is found that the flow of these fluids decreases by 95% while waking up compared to what happens during sleep, and that the size of these channels is between the vessels It can accommodate 60% when mice are asleep or in the case of anesthetic, which confirms that the body is exposed to physiological changes during the absence of consciousness increases the brain’s ability to get rid of its waste.
In a similar study on humans conducted in 2021, the neurosurgeon Pierre Christian Eddie from the Norwegian University of Oslo Hospital injecting Florian followers to follow up the flow of disabilities in a group of volunteer patients, while dividing them into two groups, where members of the first group were allowed to sleep naturally throughout the night and keep members of the second group awake during the same period.
MRI was performed for members of the two groups twice during the night and then the next day. It turned out during the experiment that the movement of fluorescent followers that monitor the flow of the sporadic fluid was very slow for volunteers who were not allowed to sleep, and it also appeared that even after they were allowed to sleep the next night, the rate of the flow of the sperm liquid has remained slow compared to the members of the other group, which indicates that the effects of sleep deprivation cannot be easily compensated by just sleeping the next night.
Eddie stressed that “despite the difference in the mechanism of the work of the glyvia system between humans and mice in general, as changes occur in the human mind within hours and not within minutes like mice, it is certain that the human mind also washed during sleep, and that the lack of sleep actually affects the mechanism of work of this system.”