Researchers have created a new way to distinguish elderly human cells from the younger cells using the electrical separation. The new method provides an appropriate tool for aging research and may also open horizons in examining medicines and renewal medicine that is concerned with renewing damaged tissues.
Scientific evidence indicates the role of elderly cells in cases associated with aging, such as atherosclerosis, Alzheimer’s disease, and type 2 diabetes. To understand and treat these diseases, scientists need to understand how hacker cells affect the body’s functions. This starts to separate the hazard cells from the young cells.
Despite the discovery of signs of elderly cells, available methods require chemical marks on cells, which may spoil their properties and make them unsuitable for study, while the new method does not require signs and causing less damage to the cell.
The study was conducted by researchers from the Japanese University of Tokyo Metropolitan, and its results were published in the IEEEE SEESORS JOURNAL sensor on June 11, and the Yurrick Alierte website wrote about it.
And aging begins at the cell level, and with age the elderly cells accumulate in the body, and not only the loss of these cells to a large part of their original function, but rather it releases compounds that cause inflammation.
Cell frequency between the poles
The current methods of separating the cells depend on what is known as selective medal, such as linking a fluorescent molecule (emitting light) with specific compounds known to be present in the hacker cells, and this method takes a long time and complex procedures, but the process itself may change the properties of the cells that scientists want to study.
Changes in the cell membrane during aging change the electrical properties of elderly cells and arise from changes in the fatty molecules that make up the cell membrane.
The researchers exploited the changes in the electrical properties of the cell to overcome the problems of the roads used to separate the cells currently.
The researchers put the cells under the alternating electric field that leads to a slight rearrangement of the shipment, as one of the two ends of the cell becomes charged with a more positive charge than the other side, and when the electric field intensity is irregular around the cell, it moves, and in the event of an alternating electric field, the cell fluctuates back and forth between the electric electrodes.
When changing the frequency of the electric field, the cell movement behavior changes significantly at a value known as the cutting frequency, this method, known as the frequency-modulated dilectrophoresis, is to determine the cell type by measuring this value.
The team has focused its efforts on human skin fibroblasts, an important part of the connective tissue in the skin. When they tested the hazard cells versus young cells, they found a remarkable difference in their cut frequencies.