Researchers have been able to move microscopic vesicles carrying magnetic drugs towards their goals, which contributes to the development of accurate medicine to treat diseases such as cancer. The targeted drug delivery and careful medicine systems offer a promising approach to enhancing the effectiveness of medicines while reducing their side effects by launching them in the target place only and controlling this time.
The study was conducted by a research team from several universities led by Professor of Science and Mechanical Engineering at the Greenger College of Engineering at the University of Illinois Urbana Chambine in the United States, Ji Feng, and its results were published in the “Nanoskil” magazine issued by the Royal Chemistry Association last May, and was written by the Yurik Alrt.
This work is based on previous results showing the possibility of fatty vesicles engineering to release medications when the laser light is shed on it. He says Feng: “The attractiveness of the fatty vesicles is to connect medications that their structure is similar to the cell, so they can only interact with certain types of cells, which is a great advantage of treating cancer.”
Feng pointed out that the current medical techniques – such as MRI – can be re -employed to direct the delivery of medicines using their magnetic fields, especially since these fields are designed to penetrate the human body, and this can be achieved by ancient magnetic packaging inside the vesicle carrying the medicine, to interact with the externally controlled magnetic field.
Vesicle
The first step in creating a magnetic -guided fatty vesicles was to develop a reliable way to wrap magnetic particles in the vesicles. Magnetic particles are small -sized molecules that spread in liquid, and can be activated remotely when applying accurate external magnetic fields.
The graduate student of Illinois Greenger’s engineering in the feng laboratory and the co -author of the study, Vinite Malik, used the “inverted emulsion” method, where magnetic particles are added to a solution of melted fat, which leads to the formation of fatty drops around the particles, and the researchers then showed that magnetic fields can direct the fatty vesicles.
The owner of the 3D printable base developed to stabilize the magnets tightly on a microscope and put the vesicles in a solution between the magnets.
The researchers noted by monitoring the resulting movement how the speed varies with the percentage of the magnetic particle size to the size of the vesicle, and it was also necessary to understand how the magnetic particle pushes the vesicle from the inside to understand the behavior of the entire device.
Illinois researchers collaborated with researchers at the University of Santa Clara to study the internal dynamics of the vesicle, a computer, to predict the speed of movement, and noticed how the magnetic particle pulled the entire Qella when it is moved through a magnetic field.
Malik says: “We are working on the next step: Using a real drug and conducting a laboratory in a system that simulates the properties of biological environments,” Malik says.