A new study revealed that high levels of a hormone present in the intestinal cells can contribute to many cases of chronic diarrhea, and the results help explain up to 40% of cases of patients with irritable bowel syndrome with diarrhea, and research results may help develop a blood test and develop new treatments.
The study was conducted by scientists from the University of Cambridge in the United Kingdom, and its results were published in the Journal (GUT) on July 23, and the Yorik Alrt website was written about.
The liver reaches bile acid when eating to break the fat so that it can be absorbed into the body, and the bile acid is released into the upper end of the small intestine, then absorbed again in the body at the bottom end.
Almost one in every 100 is infected with a condition known as the diarrhea of bile acids (also known as the malabsori of bile acids), as the bile acid is not properly absorbed, and makes its way to the large intestine (colon), and it can cause urgent water diarrhea, and patients may be exposed to the risk of stool incontinence.
It is difficult to diagnose the diarrhea of bile acids due to the lack of routine clinical blood tests, and many individuals are diagnosed with irritable bowel syndrome, a comprehensive term for a group of disorders associated with the digestive system.
It is believed that one in every 20 is infected with irritable bowel syndrome, and it is estimated that one in three patients suffers from diarrhea as a major symptom with an unjustous bile acid diarrhea.
Studies conducted on the mice previously indicated that the intestinal hormone known as the Insulin-Like Peptide 5-found in the cells in the distant end of the colon and rectal-may play a role in chronic diarrhea, and these cells secrete the hormone when it is irritated with yellow acid.
Insulin -like hormone
The researchers explore whether this hormone may also be a cause of chronic diarrhea in humans, and this is possible thanks to a new antibody test developed by the drug company Eli Lily with which the research team cooperates, and this test allows to measure small amounts of insulin -like peptide 5.
A study conducted at the Australian University of Adelaide discussed ways to stimulate the launch of the GLP-1 bowel hormone-the hormone on which weight loss drugs depend-that giving an enema with bile acid to the healthy volunteers that motivated the GLP 1, but it had an unintended effect which is to cause diarrhea. When the research team analyzed samples from this study, they found that an anal bile acid syringe caused an insulin -similar peptide level temporarily, and the higher the hormone levels, the higher the volunteer’s need for the use of the toilet.
These results suggest that insulin -like peptide 5 may play a role in cases of chronic diarrhea, when the team analyzed samples of patients suffering from bile acid diarrhea and found that while the levels of insulin -like peptide 5 were almost non -existent with healthy volunteers, they were much higher in patients with bile acid diarrhea, and in addition to that the higher the level of insulin -like peptide 5, increased, increased. The liquidity of their stool samples.
“This was a very exciting result because it showed us that this hormone may play a major role in the symptoms of this condition that is misunderstood, as this means that we may allow us to develop a blood test to help diagnose the diarrhea of bile acid if the levels of insulin -like peptide are only 5 high among these individuals,” said Dr. Chris Bannon of the University of Cambridge and the co -author of the study.